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5 htr2a  (Bioss)


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    Structured Review

    Bioss 5 htr2a
    Network pharmacology predicts the action target of PTL. ( A ) Target gene of PTL obtained from Swiss target prediction. ( B ) Target gene of PTL on Sepsis. ( C ) KEGG enrichment pathway. ( D ) Venn diagram. ( E ) Western blot of <t>5-HTR2A</t> and PKC in intestinal epithelial cells after treated with Nano PTL (n=3 independent experiments). ( F and G ) The relative expressions of 5-HTR2A and PKC (n=3 independent experiments). *P<0.05, compared with Normal. # P<0.05, compared with the LPS group. @ P<0.05, compared with the PTL group.
    5 Htr2a, supplied by Bioss, used in various techniques. Bioz Stars score: 92/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/5 htr2a/product/Bioss
    Average 92 stars, based on 2 article reviews
    5 htr2a - by Bioz Stars, 2026-03
    92/100 stars

    Images

    1) Product Images from "Nano Parthenolide Improves Intestinal Barrier Function of Sepsis by Inhibiting Apoptosis and ROS via 5-HTR2A"

    Article Title: Nano Parthenolide Improves Intestinal Barrier Function of Sepsis by Inhibiting Apoptosis and ROS via 5-HTR2A

    Journal: International Journal of Nanomedicine

    doi: 10.2147/IJN.S394544

    Network pharmacology predicts the action target of PTL. ( A ) Target gene of PTL obtained from Swiss target prediction. ( B ) Target gene of PTL on Sepsis. ( C ) KEGG enrichment pathway. ( D ) Venn diagram. ( E ) Western blot of 5-HTR2A and PKC in intestinal epithelial cells after treated with Nano PTL (n=3 independent experiments). ( F and G ) The relative expressions of 5-HTR2A and PKC (n=3 independent experiments). *P<0.05, compared with Normal. # P<0.05, compared with the LPS group. @ P<0.05, compared with the PTL group.
    Figure Legend Snippet: Network pharmacology predicts the action target of PTL. ( A ) Target gene of PTL obtained from Swiss target prediction. ( B ) Target gene of PTL on Sepsis. ( C ) KEGG enrichment pathway. ( D ) Venn diagram. ( E ) Western blot of 5-HTR2A and PKC in intestinal epithelial cells after treated with Nano PTL (n=3 independent experiments). ( F and G ) The relative expressions of 5-HTR2A and PKC (n=3 independent experiments). *P<0.05, compared with Normal. # P<0.05, compared with the LPS group. @ P<0.05, compared with the PTL group.

    Techniques Used: Western Blot

    Protective effect of Nano PTL on ROS and apoptosis of intestinal epithelial cells through 5-HTR2A. ( A ) ROS level of intestinal epithelial cells (bar, 20 µm, n=3 independent experiments). ( B ) The effect of Nano PTL on the expression of apoptosis-related proteins Bax, CytC and cleaved-Caspase3 (n=3 independent experiments). Analysis of relative expressions of ( C ) Bax, ( D ) CytC, and ( E ) cleaved-Caspase3. ( F ) Flow cytometry of apoptosis. ( G ) Effect of 5HT-Inhibitor on TEER (n=3 independent experiments). ( H ) The schematic diagram for the mechanism of the therapeutic effect of Nano PTL on intestinal barrier function after sepsis. *P<0.05, compared with Normal. # P<0.05, compared with the LPS group. @ P<0.05, compared with the PTL group Δ P<0.05, compared with the Nano PTL group.
    Figure Legend Snippet: Protective effect of Nano PTL on ROS and apoptosis of intestinal epithelial cells through 5-HTR2A. ( A ) ROS level of intestinal epithelial cells (bar, 20 µm, n=3 independent experiments). ( B ) The effect of Nano PTL on the expression of apoptosis-related proteins Bax, CytC and cleaved-Caspase3 (n=3 independent experiments). Analysis of relative expressions of ( C ) Bax, ( D ) CytC, and ( E ) cleaved-Caspase3. ( F ) Flow cytometry of apoptosis. ( G ) Effect of 5HT-Inhibitor on TEER (n=3 independent experiments). ( H ) The schematic diagram for the mechanism of the therapeutic effect of Nano PTL on intestinal barrier function after sepsis. *P<0.05, compared with Normal. # P<0.05, compared with the LPS group. @ P<0.05, compared with the PTL group Δ P<0.05, compared with the Nano PTL group.

    Techniques Used: Expressing, Flow Cytometry



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    Image Search Results


    Network pharmacology predicts the action target of PTL. ( A ) Target gene of PTL obtained from Swiss target prediction. ( B ) Target gene of PTL on Sepsis. ( C ) KEGG enrichment pathway. ( D ) Venn diagram. ( E ) Western blot of 5-HTR2A and PKC in intestinal epithelial cells after treated with Nano PTL (n=3 independent experiments). ( F and G ) The relative expressions of 5-HTR2A and PKC (n=3 independent experiments). *P<0.05, compared with Normal. # P<0.05, compared with the LPS group. @ P<0.05, compared with the PTL group.

    Journal: International Journal of Nanomedicine

    Article Title: Nano Parthenolide Improves Intestinal Barrier Function of Sepsis by Inhibiting Apoptosis and ROS via 5-HTR2A

    doi: 10.2147/IJN.S394544

    Figure Lengend Snippet: Network pharmacology predicts the action target of PTL. ( A ) Target gene of PTL obtained from Swiss target prediction. ( B ) Target gene of PTL on Sepsis. ( C ) KEGG enrichment pathway. ( D ) Venn diagram. ( E ) Western blot of 5-HTR2A and PKC in intestinal epithelial cells after treated with Nano PTL (n=3 independent experiments). ( F and G ) The relative expressions of 5-HTR2A and PKC (n=3 independent experiments). *P<0.05, compared with Normal. # P<0.05, compared with the LPS group. @ P<0.05, compared with the PTL group.

    Article Snippet: Antibodies for 5-HTR2A (Cat. bs-20743R), PKC (Cat. bs-3531R) were purchased from Bioss (China).

    Techniques: Western Blot

    Protective effect of Nano PTL on ROS and apoptosis of intestinal epithelial cells through 5-HTR2A. ( A ) ROS level of intestinal epithelial cells (bar, 20 µm, n=3 independent experiments). ( B ) The effect of Nano PTL on the expression of apoptosis-related proteins Bax, CytC and cleaved-Caspase3 (n=3 independent experiments). Analysis of relative expressions of ( C ) Bax, ( D ) CytC, and ( E ) cleaved-Caspase3. ( F ) Flow cytometry of apoptosis. ( G ) Effect of 5HT-Inhibitor on TEER (n=3 independent experiments). ( H ) The schematic diagram for the mechanism of the therapeutic effect of Nano PTL on intestinal barrier function after sepsis. *P<0.05, compared with Normal. # P<0.05, compared with the LPS group. @ P<0.05, compared with the PTL group Δ P<0.05, compared with the Nano PTL group.

    Journal: International Journal of Nanomedicine

    Article Title: Nano Parthenolide Improves Intestinal Barrier Function of Sepsis by Inhibiting Apoptosis and ROS via 5-HTR2A

    doi: 10.2147/IJN.S394544

    Figure Lengend Snippet: Protective effect of Nano PTL on ROS and apoptosis of intestinal epithelial cells through 5-HTR2A. ( A ) ROS level of intestinal epithelial cells (bar, 20 µm, n=3 independent experiments). ( B ) The effect of Nano PTL on the expression of apoptosis-related proteins Bax, CytC and cleaved-Caspase3 (n=3 independent experiments). Analysis of relative expressions of ( C ) Bax, ( D ) CytC, and ( E ) cleaved-Caspase3. ( F ) Flow cytometry of apoptosis. ( G ) Effect of 5HT-Inhibitor on TEER (n=3 independent experiments). ( H ) The schematic diagram for the mechanism of the therapeutic effect of Nano PTL on intestinal barrier function after sepsis. *P<0.05, compared with Normal. # P<0.05, compared with the LPS group. @ P<0.05, compared with the PTL group Δ P<0.05, compared with the Nano PTL group.

    Article Snippet: Antibodies for 5-HTR2A (Cat. bs-20743R), PKC (Cat. bs-3531R) were purchased from Bioss (China).

    Techniques: Expressing, Flow Cytometry